- Protein Name
- Cyclin-G-associated kinase
- Gene Name
- GAK
- Organism
-
Homo sapiens
- Function
- Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
8 |
3 |
5.5 |
| DFG |
16 |
2 |
4.5 |
| PIF |
22 |
16 |
16.0 |
| DRS |
16 |
2 |
10.0 |
| AAS |
19 |
3 |
14.0 |
| PDIG |
25 |
9 |
16.0 |
| ATP |
23 |
4 |
14.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
3 |
3 |
0 |
0 |
0 |
3 |
0 |
0 |
3 |
2 |
0 |
|
4C59
|
0 |
3 |
0 |
16 |
0 |
0 |
0 |
15 |
0 |
0 |
9 |
14 |
0 |
|
4O38
|
8 |
6 |
16 |
16 |
0 |
0 |
0 |
19 |
0 |
0 |
25 |
16 |
0 |
|
4C58
|
0 |
10 |
0 |
16 |
0 |
0 |
0 |
14 |
0 |
0 |
15 |
14 |
0 |
|
4Y8D
|
0 |
8 |
16 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
22 |
14 |
0 |
|
AFO14976
|
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4C57
|
0 |
3 |
22 |
10 |
0 |
0 |
0 |
16 |
0 |
0 |
17 |
23 |
0 |