- Protein Name
- Mitogen-activated protein kinase kinase kinase 7
- Gene Name
- MAP3K7
- Organism
-
Homo sapiens
- Function
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
19 |
4 |
10.0 |
| DFG |
23 |
3 |
9.5 |
| DRS |
4 |
2 |
3.0 |
| MT3 |
23 |
4 |
7.0 |
| PDIG |
28 |
2 |
17.0 |
| ATP |
26 |
1 |
9.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
1 |
1 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
7 |
5 |
0 |
|
4L52
|
0 |
7 |
0 |
4 |
0 |
0 |
9 |
0 |
0 |
0 |
26 |
5 |
0 |
|
AFO43318
|
0 |
23 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2EVA
|
10 |
3 |
0 |
0 |
0 |
0 |
7 |
0 |
0 |
0 |
18 |
16 |
0 |
|
4L3P
|
0 |
3 |
0 |
0 |
0 |
0 |
15 |
0 |
0 |
0 |
25 |
12 |
0 |
|
4L53
|
0 |
12 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
19 |
7 |
0 |
|
5JGA
|
0 |
12 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
26 |
0 |
|
5JGB
|
0 |
13 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
16 |
0 |
|
4GS6
|
4 |
3 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
15 |
15 |
0 |
|
5JGD
|
19 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
25 |
0 |
|
2YIY
|
0 |
0 |
0 |
0 |
0 |
0 |
15 |
0 |
0 |
0 |
28 |
13 |
0 |
|
4O91
|
10 |
0 |
0 |
0 |
0 |
0 |
23 |
0 |
0 |
0 |
2 |
17 |
0 |