- Protein Name
- Serine/threonine-protein kinase MRCK alpha
- Gene Name
- Cdc42bpa
- Organism
-
Rattus norvegicus
- Function
- Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DRS |
8 |
7 |
7.5 |
| EDI |
17 |
17 |
17.0 |
| LBP |
2 |
2 |
2.0 |
| ATP |
14 |
14 |
14.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4AW2
|
0 |
0 |
0 |
8 |
0 |
17 |
0 |
0 |
2 |
0 |
0 |
14 |
0 |