- Protein Name
- Calcium/calmodulin-dependent protein kinase type II
- Gene Name
- unc-43
- Organism
-
Caenorhabditis elegans
- Function
- Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. Involved in activation of ADF neurons and increased tph-1 transcription following exposure to pathogenic bacteria which leads to learned olfactory aversion to the bacteria. Implicated in the muscle regulation of spicule protraction. In conjunction with egl-2 has a role in the suppression of mating behavior under food deprivation to encourage foraging. Involved in restricting str-2 expression to only one of the two AWC neurons. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
18 |
15 |
17.0 |
| DFG |
13 |
2 |
3.0 |
| PIF |
28 |
4 |
11.0 |
| DRS |
20 |
5 |
16.0 |
| EDI |
10 |
7 |
9.0 |
| MT3 |
7 |
3 |
4.0 |
| AAS |
14 |
5 |
10.5 |
| CMP |
18 |
3 |
15.0 |
| PDIG |
22 |
4 |
15.0 |
| ATP |
17 |
14 |
15.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
3 |
0 |
2 |
3 |
0 |
0 |
0 |
0 |
0 |
1 |
2 |
2 |
0 |
|
2BDW
|
0 |
13 |
28 |
19 |
0 |
0 |
0 |
8 |
0 |
0 |
0 |
17 |
0 |
|
3KK9
|
16 |
0 |
9 |
18 |
0 |
0 |
4 |
6 |
0 |
3 |
14 |
14 |
0 |
|
3KK8
|
17 |
3 |
11 |
15 |
0 |
0 |
0 |
9 |
0 |
0 |
22 |
16 |
0 |
|
3KL8
|
18 |
0 |
22 |
20 |
0 |
10 |
7 |
14 |
0 |
18 |
20 |
15 |
0 |