- Protein Name
- Serine/threonine-protein kinase ULK1
- Gene Name
- ULK1
- Organism
-
Homo sapiens
- Function
- Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
8 |
2 |
6.0 |
| DFG |
11 |
3 |
6.0 |
| EDI |
4 |
4 |
4.0 |
| MT3 |
20 |
6 |
10.0 |
| LBP |
3 |
3 |
3.0 |
| ATP |
15 |
1 |
6.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4WNO
|
2 |
11 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
0 |
15 |
0 |
|
4WNP
|
6 |
6 |
0 |
0 |
0 |
0 |
6 |
0 |
3 |
0 |
0 |
7 |
0 |
|
AFO75385
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
5CI7
|
8 |
3 |
0 |
0 |
0 |
4 |
11 |
0 |
0 |
0 |
0 |
5 |
0 |