- Protein Name
- Serine/threonine-protein kinase/endoribonuclease IRE1
- Gene Name
- ERN1
- Organism
-
Homo sapiens
- Function
- Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
9 |
5 |
7.0 |
| DFG |
20 |
9 |
15.0 |
| DRS |
22 |
22 |
22.0 |
| EDI |
17 |
2 |
16.0 |
| MT3 |
27 |
1 |
11.0 |
| CMP |
31 |
2 |
12.5 |
| PDIG |
19 |
5 |
10.0 |
| ATP |
20 |
2 |
11.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
2 |
0 |
1 |
0 |
4 |
3 |
0 |
0 |
6 |
1 |
2 |
0 |
|
4YZD
|
0 |
0 |
0 |
0 |
0 |
0 |
15 |
0 |
0 |
31 |
0 |
2 |
0 |
|
4U6R
|
9 |
0 |
0 |
0 |
0 |
16 |
21 |
0 |
0 |
16 |
7 |
9 |
0 |
|
AFO75460
|
0 |
20 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4YZC
|
0 |
9 |
0 |
0 |
0 |
16 |
4 |
0 |
0 |
15 |
0 |
14 |
0 |
|
4YZ9
|
0 |
0 |
0 |
22 |
0 |
16 |
19 |
0 |
0 |
17 |
5 |
17 |
0 |
|
4Z7H
|
5 |
15 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
13 |
0 |
|
3P23
|
0 |
9 |
0 |
0 |
0 |
2 |
27 |
0 |
0 |
16 |
19 |
20 |
0 |
|
4Z7G
|
0 |
18 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
10 |
0 |
11 |
0 |
|
5HGI
|
0 |
0 |
0 |
0 |
0 |
12 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |