- Protein Name
- Serine/threonine-protein kinase 16
- Gene Name
- STK16
- Organism
-
Homo sapiens
- Function
- Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
17 |
11 |
14.0 |
| DRS |
10 |
3 |
8.0 |
| MT3 |
6 |
4 |
5.0 |
| LBP |
13 |
8 |
10.5 |
| ATP |
18 |
2 |
17.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
|
2BUJ
|
0 |
11 |
0 |
10 |
0 |
0 |
6 |
0 |
13 |
0 |
0 |
18 |
0 |
|
AFO75716
|
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |