- Protein Name
- Serine/threonine-protein kinase 10
- Gene Name
- STK10
- Organism
-
Homo sapiens
- Function
- Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
25 |
2 |
13.5 |
| DFG |
21 |
16 |
18.5 |
| PIF |
14 |
3 |
5.0 |
| DRS |
9 |
2 |
3.0 |
| MT3 |
23 |
1 |
9.5 |
| AAS |
24 |
7 |
16.0 |
| PDIG |
12 |
7 |
10.5 |
| ATP |
23 |
2 |
16.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
6 |
1 |
0 |
0 |
0 |
0 |
2 |
5 |
0 |
0 |
0 |
4 |
0 |
|
4USD
|
20 |
0 |
0 |
5 |
0 |
0 |
21 |
0 |
0 |
0 |
12 |
18 |
0 |
|
4AOT
|
18 |
0 |
0 |
9 |
0 |
0 |
23 |
24 |
0 |
0 |
9 |
15 |
0 |
|
2J7T
|
16 |
0 |
0 |
0 |
0 |
0 |
1 |
21 |
0 |
0 |
0 |
2 |
0 |
|
AFO94804
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
5AJQ
|
25 |
0 |
3 |
0 |
0 |
0 |
14 |
12 |
0 |
0 |
12 |
16 |
0 |
|
4EQU
|
18 |
21 |
5 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
0 |
0 |
|
4USE
|
11 |
0 |
0 |
0 |
0 |
0 |
0 |
24 |
0 |
0 |
0 |
20 |
0 |
|
4BC6
|
16 |
0 |
14 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
23 |
0 |