- Protein Name
- Mitogen-activated protein kinase kinase kinase kinase 4
- Gene Name
- MAP4K4
- Organism
-
Homo sapiens
- Function
- Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
17 |
8 |
15.0 |
| DFG |
16 |
3 |
9.5 |
| PIF |
20 |
5 |
9.0 |
| DRS |
17 |
2 |
14.5 |
| MT3 |
24 |
2 |
8.0 |
| AAS |
22 |
8 |
14.0 |
| LBP |
3 |
3 |
3.0 |
| CMP |
21 |
19 |
20.0 |
| PDIG |
12 |
2 |
8.0 |
| ATP |
26 |
2 |
12.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
8 |
1 |
1 |
1 |
0 |
0 |
4 |
4 |
0 |
3 |
0 |
5 |
0 |
|
4ZK5
|
15 |
0 |
0 |
15 |
0 |
0 |
10 |
15 |
0 |
0 |
0 |
20 |
0 |
|
AFO95819
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4OBO
|
16 |
0 |
0 |
0 |
0 |
0 |
17 |
16 |
0 |
0 |
11 |
18 |
0 |
|
4U3Y
|
11 |
0 |
0 |
2 |
0 |
0 |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4U42
|
17 |
8 |
20 |
6 |
0 |
0 |
2 |
16 |
0 |
0 |
11 |
12 |
0 |
|
4U3Z
|
16 |
0 |
5 |
0 |
0 |
0 |
19 |
14 |
0 |
0 |
7 |
0 |
0 |
|
5DI1
|
16 |
11 |
0 |
17 |
0 |
0 |
8 |
8 |
0 |
21 |
0 |
7 |
0 |
|
4U41
|
17 |
0 |
0 |
15 |
0 |
0 |
0 |
14 |
0 |
0 |
2 |
18 |
0 |
|
4OBP
|
17 |
5 |
0 |
0 |
0 |
0 |
8 |
14 |
0 |
0 |
8 |
13 |
0 |
|
4U45
|
14 |
16 |
0 |
0 |
0 |
0 |
0 |
15 |
3 |
19 |
12 |
12 |
0 |
|
4U40
|
15 |
0 |
0 |
14 |
0 |
0 |
5 |
14 |
0 |
0 |
0 |
14 |
0 |
|
4OBQ
|
17 |
0 |
9 |
0 |
0 |
0 |
18 |
16 |
0 |
0 |
11 |
26 |
0 |
|
4U43
|
15 |
0 |
0 |
0 |
0 |
0 |
5 |
22 |
0 |
20 |
8 |
13 |
0 |
|
4RVT
|
16 |
0 |
0 |
0 |
0 |
0 |
0 |
15 |
0 |
0 |
8 |
19 |
0 |
|
4U44
|
15 |
12 |
0 |
0 |
0 |
0 |
9 |
13 |
0 |
0 |
8 |
11 |
0 |