- Protein Name
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
- Gene Name
- PHKG1
- Organism
-
Oryctolagus cuniculus
- Function
- Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
23 |
5 |
7.0 |
| DEF |
10 |
7 |
8.5 |
| EDI |
14 |
9 |
13.0 |
| MT3 |
16 |
16 |
16.0 |
| AAS |
20 |
14 |
17.0 |
| PDIG |
21 |
15 |
17.5 |
| ATP |
20 |
7 |
18.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
3 |
2 |
0 |
|
1QL6
|
0 |
0 |
0 |
0 |
10 |
13 |
0 |
20 |
0 |
0 |
16 |
18 |
0 |
|
AFP00518
|
0 |
23 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
21 |
0 |
0 |
|
2PHK
|
0 |
7 |
0 |
0 |
0 |
9 |
16 |
0 |
0 |
0 |
15 |
7 |
0 |
|
1PHK
|
0 |
5 |
0 |
0 |
7 |
14 |
0 |
14 |
0 |
0 |
19 |
20 |
0 |