- Function
- Essential for release from glucose repression. It interacts and has functional relationship to the regulatory protein SNF4. Could phosphorylate CAT8. Phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, and which is required for transcriptional activation through TBP recruitment to the promoters.
Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
MPP |
16 |
2 |
11.0 |
AAS |
16 |
16 |
16.0 |
MT3 |
26 |
3 |
10.0 |
ATP |
17 |
2 |
14.0 |
DFG |
20 |
6 |
11.0 |
CMP |
16 |
3 |
14.0 |
PMP |
16 |
16 |
16.0 |
EDI |
12 |
8 |
9.0 |
PDIG |
22 |
6 |
16.5 |
PIF |
11 |
7 |
9.0 |
PDB ID |
Maximum Consensus Site Population |
MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
Total Druggable Structures per Site |
1 |
1 |
2 |
0 |
1 |
0 |
1 |
1 |
1 |
0 |
0 |
3 |
0 |
3MN3
|
12 |
0 |
21 |
0 |
14 |
0 |
0 |
0 |
0 |
8 |
0 |
16 |
0 |
3HYH
|
0 |
16 |
11 |
0 |
17 |
0 |
11 |
16 |
0 |
12 |
0 |
22 |
9 |
AFP06782
|
0 |
0 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
0 |
0 |
0 |
2FH9
|
16 |
0 |
26 |
0 |
11 |
0 |
0 |
0 |
16 |
0 |
0 |
13 |
0 |
3DAE
|
14 |
0 |
9 |
0 |
15 |
0 |
7 |
14 |
0 |
9 |
0 |
18 |
11 |