- Protein Name
- Tyrosine-protein kinase Fes/Fps
- Gene Name
- FES
- Organism
-
Homo sapiens
- Function
- Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
17 |
3 |
13.0 |
| DFG |
12 |
2 |
3.0 |
| PIF |
17 |
12 |
14.5 |
| EDI |
4 |
2 |
3.0 |
| MT3 |
2 |
2 |
2.0 |
| AAS |
2 |
2 |
2.0 |
| CMP |
21 |
5 |
15.0 |
| PDIG |
4 |
3 |
3.5 |
| ATP |
20 |
2 |
11.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
1 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
1 |
0 |
|
3CD3
|
14 |
10 |
12 |
0 |
0 |
2 |
0 |
2 |
0 |
21 |
4 |
15 |
0 |
|
3BKB
|
13 |
3 |
17 |
0 |
0 |
4 |
2 |
0 |
0 |
0 |
0 |
10 |
0 |
|
3CBL
|
12 |
2 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
15 |
0 |
13 |
0 |
|
AFP07332
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4E93
|
17 |
12 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
20 |
0 |