- Protein Name
- Proto-oncogene tyrosine-protein kinase ROS
- Gene Name
- ROS1
- Organism
-
Homo sapiens
- Function
- Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
22 |
3 |
11.0 |
| DFG |
17 |
17 |
17.0 |
| DRS |
2 |
2 |
2.0 |
| MT3 |
3 |
3 |
3.0 |
| CMP |
17 |
3 |
16.0 |
| ATP |
14 |
6 |
10.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
2 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
|
4UXL
|
22 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
6 |
0 |
|
AFP08922
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
|
3ZBF
|
18 |
0 |
0 |
2 |
0 |
0 |
3 |
0 |
0 |
17 |
0 |
14 |
0 |