P11802

Background

Protein Name
Cyclin-dependent kinase 4
Gene Name
CDK4
Organism
Homo sapiens

Annotations

Function
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MPP 2 2 2.0
AAS 11 10 10.5
MT3 20 4 13.0
LBP 20 7 8.0
ATP 20 16 17.5
DFG 30 15 22.5
EDI 27 2 14.0
PDIG 4 4 4.0
PIF 22 16 19.0

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site AAS site MT3 site LBP site ATP site DEF site DFG site CMP site PMP site EDI site DRS site PDIG site PIF site
Total Druggable Structures per Site 0 0 2 1 5 0 1 0 0 4 0 0 2
2W9F 0 0 20 7 17 0 0 0 0 0 0 0 0
3G33 2 0 11 0 18 0 0 0 0 27 0 4 0
5FWK 0 0 0 8 0 0 0 0 0 16 0 0 0
5FWL 0 10 0 0 0 0 0 0 0 0 0 0 0
2W9Z 2 0 14 0 16 0 0 0 0 19 0 0 0
2W99 0 0 17 0 20 0 0 0 0 9 0 0 16
2W96 0 11 15 20 18 0 15 0 0 5 0 0 22
AFP11802 0 0 0 0 0 0 30 0 0 0 0 0 0
5FWM 0 0 0 0 0 0 0 0 0 17 0 0 0