- Function
- Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. May play a role in cell proliferation. Required for cell viability.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
14 |
7 |
9.5 |
| PIF |
4 |
4 |
4.0 |
| DEF |
8 |
8 |
8.0 |
| EDI |
6 |
2 |
4.0 |
| MT3 |
4 |
1 |
3.0 |
| PDIG |
16 |
16 |
16.0 |
| ATP |
20 |
1 |
14.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
5 |
0 |
|
4FI1
|
0 |
10 |
0 |
0 |
0 |
0 |
4 |
0 |
0 |
0 |
0 |
17 |
0 |
|
4JQE
|
0 |
10 |
4 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
16 |
18 |
0 |
|
4MWH
|
0 |
9 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
20 |
0 |
|
4LFI
|
0 |
8 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
16 |
0 |
|
AFP15790
|
0 |
14 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4JR7
|
0 |
7 |
0 |
0 |
8 |
6 |
0 |
0 |
0 |
0 |
0 |
18 |
0 |