- Protein Name
- Beta-adrenergic receptor kinase 1
- Gene Name
- GRK2
- Organism
-
Bos taurus
- Function
- Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
22 |
4 |
12.0 |
| PIF |
18 |
8 |
12.0 |
| DRS |
21 |
3 |
13.0 |
| MT3 |
23 |
2 |
10.0 |
| AAS |
14 |
4 |
9.0 |
| CMP |
14 |
6 |
8.0 |
| PDIG |
4 |
2 |
3.0 |
| ATP |
21 |
6 |
17.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
4 |
2 |
4 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
10 |
0 |
|
AFP21146
|
0 |
14 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
1OMW
|
0 |
12 |
18 |
16 |
0 |
0 |
0 |
6 |
0 |
7 |
2 |
20 |
0 |
|
3PSC
|
0 |
21 |
13 |
14 |
0 |
0 |
0 |
9 |
0 |
8 |
4 |
18 |
0 |
|
3UZS
|
0 |
8 |
11 |
11 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
|
2BCJ
|
0 |
22 |
0 |
13 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
21 |
0 |
|
5HE0
|
0 |
17 |
0 |
21 |
0 |
0 |
10 |
0 |
0 |
0 |
0 |
16 |
0 |
|
5HE3
|
0 |
19 |
0 |
18 |
0 |
0 |
2 |
4 |
0 |
14 |
0 |
17 |
0 |
|
1YM7
|
0 |
10 |
0 |
13 |
0 |
0 |
7 |
9 |
0 |
6 |
0 |
19 |
0 |
|
3UZT
|
0 |
0 |
0 |
14 |
0 |
0 |
23 |
14 |
0 |
0 |
0 |
19 |
0 |
|
3PVU
|
0 |
13 |
17 |
13 |
0 |
0 |
0 |
11 |
0 |
7 |
0 |
17 |
0 |
|
3PVW
|
0 |
9 |
11 |
15 |
0 |
0 |
21 |
11 |
0 |
8 |
0 |
17 |
0 |
|
5HE2
|
0 |
12 |
0 |
16 |
0 |
0 |
0 |
5 |
0 |
12 |
3 |
17 |
0 |