- Protein Name
- Receptor tyrosine-protein kinase erbB-3
- Gene Name
- ERBB3
- Organism
-
Homo sapiens
- Function
- Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
21 |
10 |
18.0 |
| DFG |
19 |
19 |
19.0 |
| DRS |
6 |
1 |
4.0 |
| EDI |
7 |
7 |
7.0 |
| MT3 |
32 |
2 |
17.0 |
| CMP |
3 |
3 |
3.0 |
| PDIG |
11 |
2 |
3.5 |
| ATP |
23 |
5 |
16.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
4 |
1 |
0 |
0 |
0 |
0 |
6 |
0 |
0 |
0 |
0 |
4 |
0 |
|
4RIW
|
18 |
0 |
0 |
0 |
0 |
0 |
30 |
0 |
0 |
0 |
11 |
15 |
0 |
|
3KEX
|
21 |
0 |
0 |
0 |
0 |
0 |
24 |
0 |
0 |
0 |
3 |
18 |
0 |
|
4RIY
|
16 |
0 |
0 |
0 |
0 |
0 |
25 |
0 |
0 |
0 |
0 |
15 |
0 |
|
AFP21860
|
0 |
19 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4OTW
|
10 |
0 |
0 |
1 |
0 |
0 |
32 |
0 |
0 |
0 |
0 |
16 |
0 |
|
3LMG
|
14 |
0 |
0 |
6 |
0 |
0 |
27 |
0 |
0 |
3 |
4 |
23 |
0 |
|
4RIX
|
18 |
0 |
0 |
0 |
0 |
7 |
30 |
0 |
0 |
0 |
0 |
17 |
0 |