- Function
- Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. Seems to be involved in the phosphorylation of RPH1.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
9 |
8 |
8.5 |
| DFG |
5 |
5 |
5.0 |
| PIF |
5 |
5 |
5.0 |
| EDI |
2 |
2 |
2.0 |
| AAS |
25 |
16 |
20.5 |
| CMP |
20 |
11 |
16.0 |
| PDIG |
12 |
12 |
12.0 |
| ATP |
16 |
15 |
15.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
2 |
0 |
1 |
0 |
|
4PDS
|
9 |
5 |
0 |
0 |
0 |
2 |
0 |
16 |
0 |
20 |
0 |
16 |
0 |
|
4PDP
|
8 |
0 |
5 |
0 |
0 |
0 |
0 |
25 |
0 |
16 |
12 |
15 |
0 |