P23458

Background

Protein Name
Tyrosine-protein kinase JAK1
Gene Name
JAK1
Organism
Homo sapiens

Annotations

Function
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MPP 24 1 4.0
DFG 21 2 13.0
PIF 9 1 5.0
DRS 20 18 19.0
EDI 2 2 2.0
MT3 22 3 12.5
AAS 15 9 14.0
CMP 6 2 4.0
PDIG 19 13 18.0
ATP 18 1 6.0

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site DFG site PIF site DRS site DEF site EDI site MT3 site AAS site LBP site CMP site PDIG site ATP site PMP site
Total Druggable Structures per Site 3 4 0 2 0 0 6 0 0 0 3 4 0
4IVC 0 16 0 0 0 0 0 0 0 0 18 16 0
4L01 12 0 9 20 0 0 4 0 0 0 0 0 0
4K77 0 13 0 0 0 0 4 15 0 4 0 17 0
5HX8 0 14 0 0 0 0 0 0 0 0 0 3 0
4FK6 0 9 0 0 0 0 8 0 0 6 0 3 0
4IVB 2 12 0 0 0 0 0 0 0 0 0 15 0
4IVD 0 0 0 0 0 0 17 14 0 0 0 18 0
4E4N 0 0 0 0 0 0 20 0 0 4 0 3 0
5E1E 0 17 0 0 0 0 0 0 0 2 14 7 0
4E5W 0 0 0 0 0 0 16 0 0 2 0 11 0
4I5C 0 0 0 0 0 0 16 0 0 0 0 14 0
4L00 24 2 1 18 0 0 3 0 0 0 0 13 0
4EI4 11 14 0 0 0 0 16 0 0 0 0 5 0
4EHZ 4 21 0 0 0 2 0 0 0 0 13 8 0
3EYH 18 13 0 0 0 0 0 0 0 0 0 9 0
4E4L 2 14 0 0 0 0 22 0 0 4 19 6 0
4K6Z 3 16 0 0 0 0 0 9 0 0 19 16 0
3EYG 21 10 0 0 0 0 0 0 0 0 0 7 0