- Protein Name
- Activin receptor type-2A
- Gene Name
- ACVR2A
- Organism
-
Homo sapiens
- Function
- On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
16 |
11 |
13.5 |
| DFG |
22 |
9 |
19.0 |
| MT3 |
5 |
3 |
4.0 |
| AAS |
10 |
2 |
3.5 |
| ATP |
25 |
4 |
19.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
1 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
0 |
|
AFP27037
|
0 |
20 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3SOC
|
0 |
18 |
0 |
0 |
0 |
0 |
0 |
5 |
0 |
0 |
0 |
25 |
0 |
|
4ASX
|
16 |
19 |
0 |
0 |
0 |
0 |
3 |
5 |
0 |
0 |
0 |
18 |
0 |
|
3Q4T
|
11 |
22 |
0 |
0 |
0 |
0 |
5 |
10 |
0 |
0 |
0 |
22 |
0 |