- Protein Name
- MAP/microtubule affinity-regulating kinase 3
- Gene Name
- MARK3
- Organism
-
Homo sapiens
- Function
- Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
24 |
20 |
21.5 |
| EDI |
11 |
6 |
8.5 |
| MT3 |
14 |
2 |
7.0 |
| AAS |
20 |
5 |
10.0 |
| ATP |
17 |
6 |
11.0 |
| PMP |
4 |
2 |
3.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
1 |
0 |
|
2QNJ
|
21 |
0 |
0 |
0 |
0 |
0 |
9 |
20 |
0 |
0 |
0 |
14 |
4 |
|
3FE3
|
24 |
0 |
0 |
0 |
0 |
11 |
14 |
17 |
0 |
0 |
0 |
17 |
0 |
|
AFP27448
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |