- Protein Name
- Rhodopsin kinase
- Gene Name
- GRK1
- Organism
-
Bos taurus
- Function
- Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
17 |
17 |
17.0 |
| AAS |
18 |
2 |
14.5 |
| MT3 |
17 |
4 |
16.0 |
| ATP |
23 |
2 |
10.5 |
| DFG |
7 |
2 |
3.5 |
| EDI |
17 |
2 |
14.0 |
| DRS |
28 |
2 |
12.0 |
| PDIG |
4 |
4 |
4.0 |
| PIF |
29 |
1 |
15.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
1 |
2 |
3 |
0 |
9 |
0 |
0 |
0 |
0 |
3 |
2 |
0 |
9 |
|
3QC9
|
0 |
0 |
17 |
0 |
21 |
0 |
0 |
0 |
0 |
0 |
12 |
0 |
24 |
|
3C4Y
|
0 |
0 |
0 |
0 |
9 |
0 |
7 |
0 |
0 |
0 |
7 |
0 |
29 |
|
4L9I
|
0 |
0 |
0 |
0 |
21 |
0 |
0 |
0 |
0 |
16 |
12 |
0 |
22 |
|
3C50
|
0 |
0 |
0 |
0 |
16 |
0 |
4 |
0 |
0 |
14 |
11 |
0 |
23 |
|
4WBO
|
0 |
0 |
0 |
0 |
19 |
0 |
0 |
0 |
0 |
16 |
13 |
0 |
15 |
|
3C4X
|
0 |
14 |
15 |
0 |
20 |
0 |
3 |
0 |
0 |
13 |
8 |
0 |
23 |
|
3C4W
|
0 |
16 |
17 |
0 |
23 |
0 |
0 |
0 |
0 |
17 |
14 |
0 |
25 |
|
AFP28327
|
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3C51
|
0 |
0 |
4 |
0 |
12 |
0 |
4 |
0 |
0 |
2 |
28 |
0 |
22 |
|
3T8O
|
0 |
18 |
0 |
0 |
16 |
0 |
2 |
0 |
0 |
13 |
8 |
4 |
27 |
|
4PNI
|
0 |
15 |
0 |
0 |
21 |
0 |
3 |
0 |
0 |
14 |
16 |
0 |
23 |
|
3C4Z
|
0 |
0 |
16 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
12 |
0 |
15 |