- Protein Name
- Ephrin type-A receptor 3
- Gene Name
- EPHA3
- Organism
-
Homo sapiens
- Function
- Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
8 |
2 |
5.0 |
| DFG |
15 |
2 |
7.5 |
| PIF |
18 |
1 |
15.0 |
| DRS |
27 |
1 |
21.0 |
| EDI |
16 |
2 |
3.0 |
| AAS |
16 |
3 |
12.0 |
| CMP |
21 |
3 |
12.0 |
| PDIG |
11 |
5 |
6.0 |
| ATP |
26 |
1 |
13.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
6 |
23 |
0 |
1 |
0 |
2 |
0 |
9 |
0 |
14 |
0 |
|
4P5Z
|
7 |
2 |
0 |
25 |
0 |
10 |
0 |
12 |
0 |
15 |
6 |
13 |
0 |
|
4TWN
|
0 |
2 |
0 |
27 |
0 |
0 |
0 |
0 |
0 |
11 |
9 |
0 |
0 |
|
2QOC
|
8 |
7 |
0 |
22 |
0 |
0 |
0 |
0 |
0 |
18 |
0 |
25 |
0 |
|
4GK4
|
0 |
11 |
1 |
24 |
0 |
2 |
0 |
0 |
0 |
14 |
7 |
15 |
0 |
|
AFP29320
|
0 |
15 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4GK3
|
0 |
13 |
0 |
23 |
0 |
3 |
0 |
0 |
0 |
9 |
0 |
22 |
0 |
|
3DZQ
|
6 |
3 |
0 |
21 |
0 |
0 |
0 |
8 |
0 |
12 |
7 |
15 |
0 |
|
3FXX
|
6 |
7 |
0 |
4 |
0 |
0 |
0 |
0 |
0 |
21 |
11 |
17 |
0 |
|
2QOO
|
0 |
4 |
15 |
23 |
0 |
0 |
0 |
9 |
0 |
17 |
7 |
21 |
0 |
|
2QOI
|
0 |
6 |
0 |
23 |
0 |
0 |
0 |
8 |
0 |
15 |
5 |
16 |
0 |
|
2QOK
|
0 |
8 |
16 |
15 |
0 |
0 |
0 |
7 |
0 |
13 |
6 |
16 |
0 |
|
4TWO
|
0 |
15 |
17 |
13 |
0 |
0 |
0 |
12 |
0 |
9 |
0 |
18 |
0 |
|
2QOF
|
0 |
4 |
15 |
22 |
0 |
0 |
0 |
10 |
0 |
18 |
5 |
17 |
0 |
|
2QOL
|
0 |
5 |
0 |
21 |
0 |
0 |
0 |
16 |
0 |
11 |
6 |
20 |
0 |
|
3FY2
|
2 |
10 |
2 |
19 |
0 |
0 |
0 |
0 |
0 |
8 |
0 |
25 |
0 |
|
2QO2
|
0 |
6 |
0 |
23 |
0 |
0 |
0 |
13 |
0 |
18 |
6 |
17 |
0 |
|
2QOB
|
0 |
9 |
16 |
17 |
0 |
0 |
0 |
0 |
0 |
9 |
0 |
21 |
0 |
|
2QO9
|
6 |
5 |
13 |
26 |
0 |
0 |
0 |
0 |
0 |
8 |
10 |
15 |
0 |
|
2QOD
|
0 |
3 |
15 |
23 |
0 |
0 |
0 |
12 |
0 |
10 |
5 |
14 |
0 |
|
2QON
|
0 |
10 |
0 |
20 |
0 |
0 |
0 |
0 |
0 |
13 |
5 |
8 |
0 |
|
4P5Q
|
0 |
13 |
11 |
24 |
0 |
0 |
0 |
0 |
0 |
18 |
0 |
14 |
0 |
|
2QO7
|
4 |
13 |
14 |
17 |
0 |
0 |
0 |
15 |
0 |
16 |
9 |
10 |
0 |
|
4G2F
|
0 |
5 |
18 |
18 |
0 |
3 |
0 |
14 |
0 |
16 |
6 |
26 |
0 |
|
2QOQ
|
5 |
9 |
17 |
25 |
0 |
0 |
0 |
0 |
0 |
10 |
8 |
10 |
0 |
|
2GSF
|
3 |
11 |
16 |
19 |
0 |
0 |
0 |
16 |
0 |
13 |
6 |
11 |
0 |
|
4P4C
|
0 |
10 |
0 |
24 |
0 |
0 |
0 |
12 |
0 |
16 |
0 |
9 |
0 |
|
4GK2
|
4 |
6 |
0 |
20 |
0 |
16 |
0 |
13 |
0 |
4 |
5 |
18 |
0 |