P29323

Background

Protein Name
Ephrin type-B receptor 2
Gene Name
EPHB2
Organism
Homo sapiens

Annotations

Function
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MPP 2 2 2.0
DFG 20 20 20.0
DRS 25 25 25.0
EDI 15 15 15.0
AAS 11 11 11.0
PDIG 12 12 12.0
ATP 12 12 12.0

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site DFG site PIF site DRS site DEF site EDI site MT3 site AAS site LBP site CMP site PDIG site ATP site PMP site
Total Druggable Structures per Site 0 1 0 1 0 0 0 0 0 0 0 0 0
3ZFM 2 0 0 25 0 15 0 11 0 0 12 12 0
AFP29323 0 20 0 0 0 0 0 0 0 0 0 0 0