- Protein Name
- Wee1-like protein kinase
- Gene Name
- WEE1
- Organism
-
Homo sapiens
- Function
- Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
4 |
3 |
3.5 |
| ATP |
16 |
5 |
13.0 |
| DRS |
9 |
3 |
7.0 |
| PDIG |
29 |
2 |
17.0 |
| PIF |
15 |
11 |
12.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
6 |
0 |
0 |
0 |
0 |
0 |
0 |
8 |
0 |
|
AFP30291
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2IN6
|
0 |
0 |
0 |
0 |
13 |
0 |
0 |
0 |
0 |
0 |
9 |
18 |
12 |
|
3CQE
|
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
29 |
13 |
|
1X8B
|
0 |
0 |
0 |
0 |
14 |
0 |
0 |
0 |
0 |
0 |
8 |
19 |
13 |
|
3BI6
|
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
6 |
17 |
0 |
|
3BIZ
|
4 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
7 |
18 |
0 |
|
2Z2W
|
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
7 |
19 |
12 |
|
3CR0
|
3 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
4 |
22 |
11 |
|
2IO6
|
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
3 |
18 |
15 |