- Protein Name
- G protein-coupled receptor kinase 4
- Gene Name
- GRK4
- Organism
-
Homo sapiens
- Function
- Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
25 |
7 |
11.0 |
| PIF |
19 |
19 |
19.0 |
| DRS |
2 |
2 |
2.0 |
| ATP |
29 |
29 |
29.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
|
4YHJ
|
0 |
8 |
19 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
29 |
0 |
|
AFP32298
|
0 |
25 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |