- Function
- Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
19 |
2 |
6.0 |
| PIF |
18 |
2 |
12.5 |
| DRS |
2 |
1 |
2.0 |
| MT3 |
13 |
13 |
13.0 |
| LBP |
12 |
4 |
8.0 |
| CMP |
8 |
3 |
5.5 |
| PDIG |
11 |
3 |
8.0 |
| ATP |
22 |
2 |
16.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5 |
0 |
|
3SDM
|
0 |
4 |
16 |
2 |
0 |
0 |
0 |
0 |
0 |
8 |
11 |
13 |
0 |
|
3LJ2
|
0 |
3 |
14 |
0 |
0 |
0 |
0 |
0 |
4 |
0 |
4 |
18 |
0 |
|
AFP32361
|
0 |
19 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3SDJ
|
0 |
2 |
18 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
17 |
0 |
|
2RIO
|
0 |
8 |
0 |
0 |
0 |
0 |
13 |
0 |
0 |
0 |
8 |
15 |
0 |
|
3LJ0
|
0 |
11 |
7 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
22 |
0 |
|
3FBV
|
0 |
6 |
17 |
2 |
0 |
0 |
0 |
0 |
0 |
3 |
8 |
19 |
0 |
|
3LJ1
|
0 |
15 |
11 |
1 |
0 |
0 |
0 |
0 |
12 |
0 |
11 |
19 |
0 |