- Protein Name
- Dual specificity mitogen-activated protein kinase kinase 2
- Gene Name
- MAP2K2
- Organism
-
Homo sapiens
- Function
- Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
23 |
23 |
23.0 |
| MT3 |
22 |
16 |
19.0 |
| ATP |
17 |
16 |
16.5 |
| DFG |
14 |
14 |
14.0 |
| CMP |
15 |
7 |
8.0 |
| DRS |
9 |
7 |
8.0 |
| PDIG |
8 |
4 |
6.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
1 |
0 |
1 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
1S9I
|
23 |
0 |
22 |
0 |
17 |
0 |
0 |
8 |
0 |
0 |
9 |
8 |
0 |
|
AFP36507
|
0 |
0 |
0 |
0 |
0 |
0 |
14 |
15 |
0 |
0 |
0 |
0 |
0 |