P41240

Background

Protein Name
Tyrosine-protein kinase CSK
Gene Name
CSK
Organism
Homo sapiens

Annotations

Function
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Mapping Statistics

Site
Maximum Consensus Site Population
Minimum Consensus Site Population
Median Consensus Site Population
EDI 14 12 14.0
MT3 16 6 8.0
ATP 22 2 12.5
DRS 11 11 11.0
AAS 16 2 5.0
MPP 18 4 13.0
DFG 18 9 10.0
CMP 19 13 17.0
PDIG 12 2 8.5

Mapping Results

PDB ID
Maximum Consensus Site Population
EDI site
MT3 site
PIF site
ATP site
DEF site
DRS site
AAS site
MPP site
DFG site
LBP site
CMP site
PDIG site
PMP site
Total Druggable Structures per Site 0 1 0 2 0 0 1 2 1 0 4 0 0
1BYG 0 10 0 19 0 0 0 0 0 0 18 9 0
3D7T 14 16 0 14 0 11 5 16 10 0 18 12 0
3D7U 14 8 0 22 0 0 16 18 10 0 19 2 0
AFP41240 0 0 0 0 0 0 0 0 18 0 19 0 0