- Protein Name
- Tyrosine-protein kinase CSK
- Gene Name
- CSK
- Organism
-
Homo sapiens
- Function
- Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
18 |
4 |
13.0 |
| DFG |
18 |
9 |
10.0 |
| DRS |
11 |
11 |
11.0 |
| EDI |
14 |
12 |
14.0 |
| MT3 |
16 |
6 |
8.0 |
| AAS |
16 |
2 |
5.0 |
| CMP |
19 |
13 |
17.0 |
| PDIG |
12 |
2 |
8.5 |
| ATP |
22 |
2 |
12.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
2 |
1 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
4 |
0 |
2 |
0 |
|
3D7T
|
16 |
10 |
0 |
11 |
0 |
14 |
16 |
5 |
0 |
18 |
12 |
14 |
0 |
|
AFP41240
|
0 |
18 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
19 |
0 |
0 |
0 |
|
3D7U
|
18 |
10 |
0 |
0 |
0 |
14 |
8 |
16 |
0 |
19 |
2 |
22 |
0 |
|
1BYG
|
0 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
0 |
18 |
9 |
19 |
0 |