- Protein Name
- G protein-coupled receptor kinase 6
- Gene Name
- GRK6
- Organism
-
Homo sapiens
- Function
- Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
16 |
16 |
16.0 |
| DFG |
21 |
1 |
6.5 |
| PIF |
24 |
6 |
11.0 |
| DRS |
23 |
5 |
8.0 |
| AAS |
12 |
4 |
9.0 |
| LBP |
19 |
11 |
15.0 |
| PDIG |
5 |
5 |
5.0 |
| ATP |
24 |
4 |
17.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
1 |
2 |
2 |
2 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
3 |
0 |
|
3NYN
|
16 |
2 |
14 |
18 |
0 |
0 |
0 |
12 |
11 |
0 |
0 |
24 |
0 |
|
AFP43250
|
0 |
21 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2ACX
|
0 |
17 |
21 |
7 |
0 |
0 |
0 |
10 |
0 |
0 |
0 |
17 |
0 |
|
3NYO
|
0 |
8 |
24 |
23 |
0 |
0 |
0 |
9 |
19 |
0 |
5 |
21 |
0 |