- Protein Name
- Casein kinase I isoform alpha
- Gene Name
- CSNK1A1
- Organism
-
Homo sapiens
- Function
- Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| ATP |
17 |
17 |
17.0 |
| DRS |
8 |
5 |
6.5 |
| DFG |
17 |
15 |
16.0 |
| LBP |
7 |
7 |
7.0 |
| CMP |
9 |
9 |
9.0 |
| PDB ID |
Maximum Consensus Site Population |
| EDI site |
MT3 site |
PIF site |
ATP site |
DEF site |
DRS site |
AAS site |
MPP site |
DFG site |
LBP site |
CMP site |
PDIG site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
|
5FQD
|
0 |
0 |
0 |
17 |
0 |
8 |
0 |
0 |
15 |
7 |
0 |
0 |
0 |
|
AFP48729
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
9 |
0 |
0 |