- Protein Name
- Casein kinase I isoform epsilon
- Gene Name
- CSNK1E
- Organism
-
Homo sapiens
- Function
- Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| EDI |
13 |
2 |
2.5 |
| MT3 |
19 |
3 |
4.0 |
| PIF |
27 |
4 |
12.0 |
| ATP |
24 |
1 |
14.5 |
| DEF |
22 |
7 |
14.0 |
| DRS |
21 |
2 |
3.0 |
| AAS |
5 |
2 |
2.5 |
| DFG |
20 |
3 |
7.0 |
| LBP |
16 |
8 |
12.0 |
| CMP |
15 |
2 |
5.5 |
| PDB ID |
Maximum Consensus Site Population |
| EDI site |
MT3 site |
PIF site |
ATP site |
DEF site |
DRS site |
AAS site |
MPP site |
DFG site |
LBP site |
CMP site |
PDIG site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
2 |
2 |
2 |
2 |
0 |
0 |
1 |
1 |
0 |
0 |
0 |
|
4HNI
|
0 |
19 |
27 |
21 |
17 |
21 |
3 |
0 |
0 |
16 |
3 |
0 |
0 |
|
4HOK
|
13 |
4 |
16 |
24 |
22 |
17 |
5 |
0 |
20 |
0 |
15 |
0 |
0 |