- Protein Name
- Dual specificity protein kinase CLK1
- Gene Name
- CLK1
- Organism
-
Homo sapiens
- Function
- Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
4 |
2 |
3.0 |
| DFG |
28 |
3 |
7.0 |
| DRS |
7 |
7 |
7.0 |
| EDI |
16 |
3 |
16.0 |
| MT3 |
15 |
4 |
15.0 |
| AAS |
10 |
10 |
10.0 |
| CMP |
19 |
16 |
16.0 |
| PDIG |
27 |
2 |
15.0 |
| ATP |
26 |
2 |
10.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
5 |
1 |
3 |
0 |
|
2VAG
|
2 |
3 |
0 |
0 |
0 |
16 |
0 |
10 |
0 |
19 |
15 |
26 |
0 |
|
5J1V
|
3 |
8 |
0 |
7 |
0 |
16 |
15 |
0 |
0 |
16 |
0 |
16 |
0 |
|
AFP49759
|
0 |
28 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
|
5J1W
|
0 |
7 |
0 |
7 |
0 |
16 |
15 |
0 |
0 |
16 |
2 |
16 |
0 |
|
1Z57
|
4 |
7 |
0 |
0 |
0 |
14 |
4 |
0 |
0 |
17 |
27 |
11 |
0 |