- Protein Name
- Dual specificity protein kinase CLK3
- Gene Name
- CLK3
- Organism
-
Homo sapiens
- Function
- Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
5 |
5 |
5.0 |
| DRS |
8 |
2 |
2.0 |
| EDI |
18 |
4 |
16.0 |
| MT3 |
13 |
7 |
8.0 |
| CMP |
21 |
10 |
15.0 |
| PDIG |
26 |
7 |
14.0 |
| ATP |
19 |
2 |
7.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
3 |
1 |
3 |
0 |
|
AFP49761
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
|
2EU9
|
0 |
5 |
0 |
2 |
0 |
16 |
0 |
0 |
0 |
14 |
10 |
14 |
0 |
|
2EXE
|
0 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
10 |
26 |
0 |
0 |
|
3RAW
|
0 |
5 |
0 |
8 |
0 |
0 |
13 |
0 |
0 |
21 |
14 |
17 |
0 |
|
2WU7
|
0 |
0 |
0 |
2 |
0 |
0 |
7 |
0 |
0 |
15 |
7 |
16 |
0 |
|
2WU6
|
0 |
0 |
0 |
2 |
0 |
16 |
8 |
0 |
0 |
16 |
14 |
19 |
0 |