- Protein Name
- Ephrin type-B receptor 4
- Gene Name
- EPHB4
- Organism
-
Homo sapiens
- Function
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
17 |
2 |
4.0 |
| DFG |
24 |
3 |
12.0 |
| PIF |
23 |
11 |
17.0 |
| DRS |
28 |
20 |
25.0 |
| EDI |
12 |
2 |
7.0 |
| MT3 |
2 |
2 |
2.0 |
| AAS |
11 |
11 |
11.0 |
| CMP |
2 |
2 |
2.0 |
| PDIG |
17 |
8 |
15.5 |
| ATP |
26 |
2 |
15.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
1 |
2 |
1 |
14 |
0 |
0 |
0 |
0 |
0 |
0 |
7 |
9 |
0 |
|
2VWW
|
9 |
14 |
0 |
26 |
0 |
12 |
0 |
0 |
0 |
0 |
16 |
16 |
0 |
|
2VX1
|
2 |
5 |
0 |
25 |
0 |
0 |
0 |
0 |
0 |
0 |
15 |
11 |
0 |
|
2VX0
|
0 |
3 |
0 |
24 |
0 |
2 |
0 |
0 |
0 |
0 |
16 |
15 |
0 |
|
3ZEW
|
12 |
13 |
0 |
24 |
0 |
0 |
0 |
0 |
0 |
2 |
8 |
16 |
0 |
|
4AW5
|
3 |
10 |
0 |
27 |
0 |
9 |
0 |
0 |
0 |
0 |
13 |
2 |
0 |
|
2VWY
|
3 |
0 |
0 |
25 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
15 |
0 |
|
2VWX
|
0 |
4 |
0 |
26 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
18 |
0 |
|
2VWU
|
5 |
12 |
0 |
28 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
16 |
0 |
|
2XVD
|
3 |
13 |
0 |
20 |
0 |
0 |
0 |
0 |
0 |
0 |
15 |
20 |
0 |
|
2YN8
|
0 |
4 |
0 |
26 |
0 |
0 |
2 |
11 |
0 |
0 |
13 |
26 |
0 |
|
AFP54760
|
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2X9F
|
8 |
14 |
23 |
23 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
16 |
0 |
|
4BB4
|
3 |
24 |
11 |
23 |
0 |
0 |
0 |
0 |
0 |
0 |
13 |
16 |
0 |
|
2VWZ
|
0 |
6 |
0 |
23 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
12 |
0 |
|
2VWV
|
17 |
12 |
0 |
26 |
0 |
5 |
0 |
0 |
0 |
0 |
14 |
16 |
0 |