P54762

Background

Protein Name
Ephrin type-B receptor 1
Gene Name
EPHB1
Organism
Homo sapiens

Annotations

Function
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MPP 16 2 5.0
DFG 16 10 12.5
PIF 26 13 15.5
DRS 27 24 26.0
EDI 7 2 4.0
MT3 17 17 17.0
AAS 17 6 10.0
PDIG 16 9 13.0
ATP 19 2 15.0

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site DFG site PIF site DRS site DEF site EDI site MT3 site AAS site LBP site CMP site PDIG site ATP site PMP site
Total Druggable Structures per Site 1 1 1 1 0 0 1 1 0 0 1 1 0
3ZFX 16 14 26 27 0 7 17 17 0 0 16 19 0
AFP54762 0 16 0 0 0 0 0 0 0 0 0 0 0