- Protein Name
- Ephrin type-B receptor 2
- Gene Name
- Ephb2
- Organism
-
Mus musculus
- Function
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| AAS |
16 |
6 |
14.0 |
| ATP |
22 |
2 |
12.0 |
| DFG |
17 |
3 |
8.0 |
| CMP |
6 |
4 |
6.0 |
| DRS |
24 |
18 |
23.5 |
| PDIG |
16 |
12 |
13.0 |
| PIF |
16 |
15 |
15.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
1 |
0 |
0 |
2 |
0 |
1 |
0 |
0 |
0 |
2 |
1 |
1 |
|
2HEN
|
0 |
16 |
0 |
0 |
22 |
0 |
8 |
6 |
0 |
0 |
24 |
13 |
16 |
|
AFP54763
|
0 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
|
1JPA
|
0 |
14 |
0 |
0 |
21 |
0 |
11 |
4 |
0 |
0 |
24 |
16 |
0 |