- Function
- Phosphorylates GarA. May play a role in metabolic regulation via control of the phosphorylation status of GarA. Plays a crucial role in the survival of mycobacteria within host macrophages, by blocking the intracellular degradation of mycobacteria in lysosomes. Required for intrinsic antibiotic resistance.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DRS |
8 |
3 |
5.5 |
| EDI |
13 |
10 |
11.5 |
| MT3 |
6 |
4 |
5.0 |
| AAS |
21 |
7 |
20.0 |
| CMP |
9 |
9 |
9.0 |
| PDIG |
6 |
6 |
6.0 |
| ATP |
16 |
4 |
13.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
1 |
0 |
|
2PZI
|
0 |
0 |
0 |
8 |
0 |
0 |
4 |
7 |
0 |
0 |
6 |
16 |
0 |
|
4Y0X
|
0 |
0 |
0 |
0 |
0 |
13 |
6 |
20 |
0 |
9 |
0 |
13 |
0 |
|
4Y12
|
0 |
0 |
0 |
3 |
0 |
10 |
5 |
21 |
0 |
0 |
0 |
13 |
0 |