- Function
- Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host (PubMed:24706757). Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA (PubMed:15978616, PubMed:15985609, PubMed:15987910, PubMed:16436437, PubMed:16817899, PubMed:16980473, PubMed:19121323, PubMed:19826007, PubMed:20025669, PubMed:21423706, PubMed:22275220). Also catalyzes the phosphorylation of the core proteasome alpha-subunit (PrcA), and thereby regulates the proteolytic activity of the proteasome (PubMed:25224505). Is a major regulator of the oxygen-dependent replication switch since PknB activity is necessary for reactivation of cells from the hypoxic state (PubMed:24409094). Shows a strong preference for Thr versus Ser as the phosphoacceptor. Overexpression of PknB alters cell morphology and leads to cell death (PubMed:24706757) (PubMed:24409094).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
3 |
3 |
3.0 |
| AAS |
4 |
4 |
4.0 |
| MT3 |
22 |
3 |
10.0 |
| ATP |
22 |
1 |
17.0 |
| DFG |
12 |
9 |
10.5 |
| EDI |
16 |
10 |
15.0 |
| DRS |
10 |
10 |
10.0 |
| PDIG |
18 |
4 |
9.0 |
| PIF |
4 |
2 |
3.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
0 |
2 |
0 |
4 |
0 |
0 |
0 |
0 |
2 |
0 |
3 |
0 |
|
AFP9WI81
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
|
2FUM
|
0 |
0 |
14 |
0 |
17 |
0 |
0 |
0 |
0 |
10 |
0 |
17 |
0 |
|
1MRU
|
0 |
0 |
0 |
0 |
21 |
0 |
9 |
0 |
0 |
15 |
0 |
11 |
4 |
|
1O6Y
|
3 |
4 |
22 |
0 |
22 |
0 |
0 |
0 |
0 |
16 |
10 |
7 |
0 |
|
3F69
|
0 |
0 |
22 |
0 |
21 |
0 |
0 |
0 |
0 |
15 |
0 |
18 |
2 |
|
3F61
|
0 |
0 |
10 |
0 |
15 |
0 |
12 |
0 |
0 |
16 |
0 |
11 |
0 |