Q00534

Background

Protein Name
Cyclin-dependent kinase 6
Gene Name
CDK6
Organism
Homo sapiens

Annotations

Function
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).

Mapping Statistics

Site
Maximum Consensus Site Population
Minimum Consensus Site Population
Median Consensus Site Population
EDI 32 2 15.0
MT3 23 3 8.0
PIF 17 3 14.5
ATP 31 2 18.5
AAS 10 6 9.0
MPP 18 10 16.0
DFG 15 2 3.0
LBP 9 9 9.0
CMP 5 2 3.0
PDIG 24 4 13.0

Mapping Results

PDB ID
Maximum Consensus Site Population
EDI site
MT3 site
PIF site
ATP site
DEF site
DRS site
AAS site
MPP site
DFG site
LBP site
CMP site
PDIG site
PMP site
Total Druggable Structures per Site 12 5 4 15 0 0 0 2 0 0 0 6 0
1BI7 18 5 0 14 0 0 0 0 0 0 3 24 0
1BI8 20 7 0 17 0 0 0 0 0 0 0 18 0
1BLX 16 17 0 16 0 0 0 0 0 0 0 7 0
1G3N 23 18 0 21 0 0 0 0 12 0 0 17 0
1JOW 16 0 17 31 0 0 0 18 3 0 0 16 0
1XO2 10 0 16 31 0 0 0 16 2 9 5 21 0
2EUF 23 0 12 21 0 0 0 0 0 0 0 13 0
2F2C 10 0 16 28 0 0 0 10 0 0 0 0 0
3NUP 15 7 0 22 0 0 0 0 15 0 0 7 0
3NUX 19 14 3 23 0 0 0 0 0 0 0 0 0
4AUA 30 9 0 19 0 0 0 0 0 0 0 13 0
4EZ5 31 23 0 20 0 0 0 0 0 0 0 0 0
4TTH 0 0 17 27 0 0 0 0 2 0 0 0 0
5L2I 17 5 10 23 0 0 6 0 0 0 0 21 0
5L2S 23 17 13 28 0 0 9 0 0 0 2 0 0
5L2T 32 19 0 22 0 0 10 0 0 0 3 0 0