- Protein Name
- Cyclin-dependent kinase 16
- Gene Name
- CDK16
- Organism
-
Homo sapiens
- Function
- Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
31 |
31 |
31.0 |
| EDI |
17 |
17 |
17.0 |
| MT3 |
18 |
1 |
2.0 |
| AAS |
14 |
7 |
10.5 |
| LBP |
9 |
9 |
9.0 |
| ATP |
24 |
24 |
24.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
1 |
0 |
|
3MTL
|
0 |
0 |
0 |
0 |
0 |
17 |
18 |
14 |
9 |
0 |
0 |
24 |
0 |
|
AFQ00536
|
0 |
31 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |