- Protein Name
- Tyrosine-protein kinase transmembrane receptor ROR2
- Gene Name
- ROR2
- Organism
-
Homo sapiens
- Function
- Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
8 |
3 |
6.0 |
| PIF |
10 |
10 |
10.0 |
| DRS |
18 |
18 |
18.0 |
| EDI |
16 |
10 |
12.5 |
| MT3 |
22 |
1 |
11.0 |
| CMP |
12 |
11 |
11.5 |
| PDIG |
4 |
4 |
4.0 |
| ATP |
16 |
13 |
14.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
1 |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
1 |
0 |
|
3ZZW
|
6 |
0 |
0 |
18 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
|
4GT4
|
8 |
0 |
10 |
0 |
0 |
13 |
22 |
0 |
0 |
12 |
4 |
14 |
0 |