- Function
- Constitutively active kinase, specifically and sequentially phosphorylates serine/arginine (SR)-type shuttling mRNA binding proteins in their RS dipeptide repeats.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
2 |
2 |
2.0 |
| DFG |
8 |
1 |
5.0 |
| DRS |
15 |
3 |
14.0 |
| DEF |
9 |
8 |
8.5 |
| EDI |
16 |
13 |
14.0 |
| MT3 |
17 |
2 |
8.0 |
| CMP |
22 |
18 |
21.0 |
| ATP |
20 |
3 |
10.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
6 |
0 |
4 |
0 |
|
2JD5
|
2 |
0 |
0 |
13 |
0 |
14 |
7 |
0 |
0 |
22 |
0 |
17 |
0 |
|
1HOW
|
0 |
0 |
0 |
14 |
8 |
13 |
9 |
0 |
0 |
18 |
0 |
14 |
0 |
|
1Q97
|
2 |
0 |
0 |
15 |
0 |
16 |
9 |
0 |
0 |
21 |
0 |
20 |
0 |
|
1Q8Y
|
0 |
8 |
0 |
14 |
0 |
14 |
11 |
0 |
0 |
21 |
0 |
18 |
0 |
|
1Q8Z
|
0 |
8 |
0 |
15 |
0 |
15 |
0 |
0 |
0 |
22 |
0 |
15 |
0 |
|
1Q99
|
0 |
2 |
0 |
15 |
9 |
14 |
17 |
0 |
0 |
21 |
0 |
17 |
0 |