- Function
- Acts as a negative regulator in the ethylene response pathway (PubMed:8431946). Phosphorylates the cytosolic C-terminal domain of EIN2, preventing the signaling in the absence of ethylene (PubMed:23132950).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
20 |
7 |
11.5 |
| DFG |
19 |
2 |
4.0 |
| DRS |
5 |
2 |
2.0 |
| EDI |
10 |
8 |
9.0 |
| MT3 |
27 |
1 |
18.0 |
| AAS |
7 |
7 |
7.0 |
| LBP |
3 |
3 |
3.0 |
| ATP |
20 |
4 |
14.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
1 |
1 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
1 |
0 |
|
3PPZ
|
11 |
4 |
0 |
2 |
0 |
0 |
27 |
0 |
3 |
0 |
0 |
15 |
0 |
|
3P86
|
20 |
3 |
0 |
5 |
0 |
10 |
18 |
7 |
0 |
0 |
0 |
20 |
0 |
|
AFQ05609
|
0 |
19 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |