- Protein Name
- 2-5A-dependent ribonuclease
- Gene Name
- RNASEL
- Organism
-
Homo sapiens
- Function
- Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
8 |
7 |
7.5 |
| MT3 |
9 |
9 |
9.0 |
| AAS |
6 |
2 |
4.0 |
| CMP |
23 |
5 |
21.0 |
| ATP |
19 |
9 |
16.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
1 |
0 |
|
4OAV
|
0 |
8 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
21 |
0 |
19 |
0 |
|
4OAU
|
0 |
7 |
0 |
0 |
0 |
0 |
9 |
6 |
0 |
23 |
0 |
15 |
0 |