- Function
- Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
18 |
2 |
14.0 |
| DFG |
26 |
1 |
2.0 |
| PIF |
6 |
6 |
6.0 |
| EDI |
32 |
3 |
15.0 |
| MT3 |
18 |
4 |
12.5 |
| AAS |
15 |
15 |
15.0 |
| LBP |
15 |
2 |
5.0 |
| PDIG |
16 |
2 |
3.0 |
| ATP |
29 |
1 |
21.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
1 |
1 |
0 |
0 |
0 |
3 |
3 |
0 |
0 |
0 |
1 |
4 |
0 |
|
1OB3
|
12 |
0 |
0 |
0 |
0 |
20 |
17 |
15 |
6 |
0 |
0 |
28 |
0 |
|
1V0O
|
15 |
2 |
6 |
0 |
0 |
15 |
10 |
0 |
0 |
0 |
13 |
25 |
0 |
|
1V0B
|
18 |
0 |
0 |
0 |
0 |
32 |
17 |
0 |
15 |
0 |
3 |
29 |
0 |
|
AFQ07785
|
0 |
26 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
1V0P
|
14 |
0 |
0 |
0 |
0 |
27 |
18 |
0 |
13 |
0 |
16 |
29 |
0 |