Q08345

Background

Protein Name
Epithelial discoidin domain-containing receptor 1
Gene Name
DDR1
Organism
Homo sapiens

Annotations

Function
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MPP 26 7 16.0
DFG 17 2 9.5
MT3 23 2 11.0
AAS 6 2 3.0
CMP 11 11 11.0
PDIG 18 5 16.0
ATP 22 1 8.0

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site DFG site PIF site DRS site DEF site EDI site MT3 site AAS site LBP site CMP site PDIG site ATP site PMP site
Total Druggable Structures per Site 5 1 0 0 0 0 2 0 0 0 8 5 0
5FDP 17 0 0 0 0 0 0 0 0 0 18 17 0
4CKR 7 0 0 0 0 0 23 0 0 11 16 7 0
5BVO 16 0 0 0 0 0 0 0 0 0 16 22 0
5BVK 16 0 0 0 0 0 17 3 0 0 17 6 0
5BVW 16 0 0 0 0 0 0 0 0 0 16 9 0
5BVN 26 0 0 0 0 0 5 0 0 0 16 19 0
3ZOS 13 2 0 0 0 0 0 6 0 0 16 21 0
AFQ08345 0 17 0 0 0 0 0 0 0 0 0 0 0
4BKJ 0 0 0 0 0 0 0 3 0 0 17 20 0