- Protein Name
- Mitogen-activated protein kinase kinase kinase 12
- Gene Name
- MAP3K12
- Organism
-
Homo sapiens
- Function
- May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
17 |
5 |
10.5 |
| DFG |
24 |
7 |
15.5 |
| EDI |
13 |
3 |
4.0 |
| MT3 |
13 |
2 |
5.5 |
| AAS |
17 |
17 |
17.0 |
| CMP |
16 |
9 |
9.0 |
| ATP |
21 |
2 |
20.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
2 |
1 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
1 |
0 |
4 |
0 |
|
5CEO
|
17 |
0 |
0 |
0 |
0 |
0 |
5 |
0 |
0 |
9 |
0 |
21 |
0 |
|
5CEN
|
10 |
7 |
0 |
0 |
0 |
0 |
13 |
17 |
0 |
0 |
0 |
21 |
0 |
|
5CEP
|
17 |
0 |
0 |
0 |
0 |
4 |
5 |
0 |
0 |
9 |
0 |
20 |
0 |
|
5CEQ
|
11 |
0 |
0 |
0 |
0 |
13 |
6 |
0 |
0 |
16 |
0 |
21 |
0 |
|
AFQ12852
|
0 |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |