- Protein Name
- Mitogen-activated protein kinase 7
- Gene Name
- MAPK7
- Organism
-
Homo sapiens
- Function
- Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
10 |
3 |
7.0 |
| DFG |
15 |
2 |
4.0 |
| PIF |
17 |
3 |
15.0 |
| DEF |
17 |
4 |
10.5 |
| EDI |
20 |
8 |
12.0 |
| MT3 |
21 |
2 |
10.0 |
| CMP |
3 |
3 |
3.0 |
| ATP |
15 |
2 |
8.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
1 |
0 |
1 |
5 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4IC7
|
10 |
15 |
0 |
0 |
17 |
16 |
2 |
0 |
0 |
0 |
0 |
10 |
0 |
|
4IC8
|
0 |
3 |
0 |
0 |
0 |
20 |
2 |
0 |
0 |
0 |
0 |
9 |
0 |
|
4ZSL
|
0 |
0 |
15 |
0 |
0 |
12 |
21 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4ZSJ
|
0 |
0 |
15 |
0 |
0 |
20 |
18 |
0 |
0 |
3 |
0 |
0 |
0 |
|
4B99
|
0 |
4 |
0 |
0 |
0 |
19 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
|
4ZSG
|
0 |
0 |
17 |
0 |
0 |
19 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
5BYZ
|
0 |
0 |
15 |
0 |
0 |
12 |
0 |
0 |
0 |
0 |
0 |
8 |
0 |
|
5BYY
|
0 |
5 |
0 |
0 |
0 |
8 |
0 |
0 |
0 |
0 |
0 |
15 |
0 |