- Protein Name
- Integrin-linked protein kinase
- Gene Name
- ILK
- Organism
-
Homo sapiens
- Function
- Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MT3 |
15 |
5 |
10.0 |
| ATP |
14 |
12 |
13.0 |
| DFG |
19 |
10 |
13.5 |
| CMP |
4 |
2 |
3.0 |
| PIF |
8 |
4 |
7.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3REP
|
0 |
0 |
15 |
0 |
12 |
0 |
19 |
4 |
0 |
0 |
0 |
0 |
4 |
|
3KMU
|
0 |
0 |
0 |
0 |
14 |
0 |
14 |
3 |
0 |
0 |
0 |
0 |
8 |
|
3KMW
|
0 |
0 |
5 |
0 |
12 |
0 |
13 |
2 |
0 |
0 |
0 |
0 |
7 |